Penk-rs^tm1Pig
Targeted Allele Detail

Summary

• Symbol: Penk-rs^tm1Pig
• Name: preproenkephalin, related sequence; targeted mutation 1, Pain Investigation Group
• MGI ID: MGI:2136456
• Synonyms: enk-, Penk2^tm1Zim, Penk KO, PPNK-
• Gene: Penk-rs Location: unknown Genetic Position: Chr9, Syntenic
• Alliance: Penk-rs^tm1Pig page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:35826
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neomycin resistance cassette replaced 54 bp of the 5' part of exon 3 and parts of the second intron. The mutated allele contains a rearrangement downstream from the insertion site with a partial duplication of exon 3 sequences. Northern blot analysis of brain and testis detected nearly no encoded mRNA in homozygous mice. (J:35826)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Penk-rs Mutation: 3 strains or lines available

References

• Original: J:35826 Konig M, et al., Pain responses, anxiety and aggression in mice deficient in pre-proenkephalin. Nature. 1996 Oct 10;383(6600):535-8
• All: 27 reference(s)