Vegfa^tm2Pec
Targeted Allele Detail

Summary

• Symbol: Vegfa^tm2Pec
• Name: vascular endothelial growth factor A; targeted mutation 2, Peter Carmeliet
• MGI ID: MGI:2136623
• Synonyms: Vegf^delta
• Gene: Vegfa Location: Chr17:46327919-46343295 bp, - strand Genetic Position: Chr17, 22.79 cM
• Alliance: Vegfa^tm2Pec page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:69797
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Deletion of the hypoxia-response element (HRE) in the promoter of the gene. An adajcent neomycin cassette was removed prior to blastocyst injection via Cre-mediated recombination in ES cells, resulting in the final allele. (J:69797)

Disease models

Expression

In Structures Affected by this Mutation:

14 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vegfa Mutation: 38 strains or lines available

References

• Original: J:69797 Oosthuyse B, et al., Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration. Nat Genet. 2001 Jun;28(2):131-8
• All: 11 reference(s)