Agt^tm1Afu
Targeted Allele Detail

Summary

• Symbol: Agt^tm1Afu
• Name: angiotensinogen; targeted mutation 1, Akiyoshi Fukamizu
• MGI ID: MGI:2136636
• Synonyms: AgKO, Agt-KO, Angt-KO, ATG-
• Gene: Agt Location: Chr8:125283326-125296445 bp, - strand Genetic Position: Chr8, 72.81 cM
• Alliance: Agt^tm1Afu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:21887
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 2, containing the initiation codon and sequences encoding amino acids 1-138, was replaced with a neomycin resistance gene. Northern blot analysis demonstrated that the encoded transcript was not detectable in liver of homozygous mice. (J:21887)

Expression

In Structures Affected by this Mutation:

18 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Agt Mutation: 35 strains or lines available

References

• Original: J:21887 Tanimoto K, et al., Angiotensinogen-deficient mice with hypotension. J Biol Chem. 1994 Dec 16;269(50):31334-7
• All: 34 reference(s)