Ren1^tm1Afu
Targeted Allele Detail

Summary

• Symbol: Ren1^tm1Afu
• Name: renin 1 structural; targeted mutation 1, Akiyoshi Fukamizu
• MGI ID: MGI:2136642
• Synonyms: renin-
• Gene: Ren1 Location: Chr1:133278412-133288058 bp, + strand Genetic Position: Chr1, 57.91 cM
• Alliance: Ren1^tm1Afu page

Ren1^tm1Afu/Ren1^tm1Afu mice exhibit kidney abnormalities

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:59299
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A lacZ-neomycin reistance cassette replaced the first three exons. Northern blot analysis of kidney did not detect RNA in homozygous mutant mice. (J:59299)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Ren1 Mutation: 35 strains or lines available

References

• Original: J:59299 Yanai K, et al., Renin-dependent cardiovascular functions and renin-independent blood-brain barrier functions revealed by renin-deficient mice. J Biol Chem. 2000 Jan 7;275(1):5-8
• All: 3 reference(s)