Irs1^tm1Tka
Targeted Allele Detail

Summary

• Symbol: Irs1^tm1Tka
• Name: insulin receptor substrate 1; targeted mutation 1, Takashi Kadowaki
• MGI ID: MGI:2136643
• Synonyms: IRS-1^-
• Gene: Irs1 Location: Chr1:82210822-82269137 bp, - strand Genetic Position: Chr1, 42.0 cM, cytoband C5
• Alliance: Irs1^tm1Tka page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:21373
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A PGK-neomycin cassette disrupted the first exon of the gene, preventing the production of stable mRNA transcripts. No transcript was detected in hepatic tissues of homozygous null mice by Northern blot analysis. Western blots of liver homogenates showed no detectable protein. (J:21373)

Disease models

Expression

In Structures Affected by this Mutation:

15 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Irs1 Mutation: 52 strains or lines available

References

• Original: J:21373 Tamemoto H, et al., Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1 [see comments]. Nature. 1994 Nov 10;372(6502):182-6
• All: 23 reference(s)