Gja3^tm1Scr
Targeted Allele Detail

Summary

• Symbol: Gja3^tm1Scr
• Name: gap junction protein, alpha 3; targeted mutation 1, The Scripps Research Institute
• MGI ID: MGI:2136656
• Synonyms: alpha3^-, alpha3Cx46^-, Cx46^lacZ, Gja3^tm1
• Gene: Gja3 Location: Chr14:57271917-57295487 bp, - strand Genetic Position: Chr14, 29.82 cM
• Alliance: Gja3^tm1Scr page

Dense nuclear cataracts in Gja8^R205G/Gja8^R205G and Gja8^R205G/Gja8^R205G Gja3^tm1Scr/Gja3^tm1Scr mice but degenerating peripheral lens fibers only in Gja8^R205G/Gja8^R205G mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:44949
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A DNA fragment encoding the four putative transmembrane domains was replaced with a lacZ gene and a neomycin cassette. No mRNA was expressed by this allele, as assessed by Northern blot on total RNA derived from homozygous mutant lens tissue. (J:44949)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gja3 Mutation: 17 strains or lines available

References

• Original: J:44949 Gong X, et al., Disruption of alpha3 connexin gene leads to proteolysis and cataractogenesis in mice. Cell. 1997 Dec 12;91(6):833-43
• All: 23 reference(s)