Il18^tm1Aki
Targeted Allele Detail

Summary

• Symbol: Il18^tm1Aki
• Name: interleukin 18; targeted mutation 1, Shizuo Akira
• MGI ID: MGI:2136769
• Synonyms: Il18-, IL-18, IL-18-, IL-18KO
• Gene: Il18 Location: Chr9:50466127-50493140 bp, + strand Genetic Position: Chr9, 27.75 cM
• Alliance: Il18^tm1Aki page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:46514
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Replacement of exons 3, 4 and 5 with a neomycin resistance gene inserted in frame into exon 3. By Northern blot analysis, mRNA could not be detected in macrophages derived from homozygous mutant mice. By ELISA assay, protein cound not be detected in serum of homozygous mutant mice after intravenous injection of lipopolysaccharide. (J:46514)

Expression

In Mice Carrying this Mutation:	32 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Il18 Mutation: 32 strains or lines available

References

• Original: J:46514 Takeda K, et al., Defective NK cell activity and Th1 response in IL-18-deficient mice. Immunity. 1998 Mar;8(3):383-90
• All: 229 reference(s)