Itgae^tm1Cmp
Targeted Allele Detail

Summary

• Symbol: Itgae^tm1Cmp
• Name: integrin alpha E, epithelial-associated; targeted mutation 1, Christina M Parker
• MGI ID: MGI:2136817
• Synonyms: alphaE-, CD103^-
• Gene: Itgae Location: Chr11:72981409-73038272 bp, + strand Genetic Position: Chr11, 45.22 cM
• Alliance: Itgae^tm1Cmp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:55333
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Replacement of exon 10 with a neomycin resistance gene. No Itgae expression is detected in intraepithelial lymphocytes (IEL) by FACS analysis. (J:55333)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Itgae Mutation: 83 strains or lines available

References

• Original: J:55333 Schon MP, et al., Mucosal T lymphocyte numbers are selectively reduced in integrin alpha E (CD103)-deficient mice. J Immunol. 1999 Jun 1;162(11):6641-9
• All: 37 reference(s)