Gdnf^tm1Bbd
Targeted Allele Detail

Summary

• Symbol: Gdnf^tm1Bbd
• Name: glial cell line derived neurotrophic factor; targeted mutation 1, Mariano Barbacid
• MGI ID: MGI:2136844
• Synonyms: Gdnf^LacZ, GDNF/lacZ
• Gene: Gdnf Location: Chr15:7840327-7867056 bp, + strand Genetic Position: Chr15, 3.8 cM
• Alliance: Gdnf^tm1Bbd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:33809
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A lacZ gene was inserted in-frame into the first coding exon. A neomycin resistance cassette was also inserted following the lacZ gene. This allele expresses a fusion protein consisting of the first 8 amino acids of GDNF fused to beta-galactosidase. (J:33809)

Expression

In Structures Affected by this Mutation:

12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gdnf Mutation: 19 strains or lines available

References

• Original: J:33809 Sanchez MP, et al., Renal agenesis and the absence of enteric neurons in mice lacking GDNF. Nature. 1996 Jul 4;382(6586):70-3
• All: 14 reference(s)