Gdnf^tm2Bbd
Targeted Allele Detail

Summary

• Symbol: Gdnf^tm2Bbd
• Name: glial cell line derived neurotrophic factor; targeted mutation 2, Mariano Barbacid
• MGI ID: MGI:2136845
• Synonyms: Gdnf^-, GDNF/neo
• Gene: Gdnf Location: Chr15:7840327-7867056 bp, + strand Genetic Position: Chr15, 3.8 cM
• Alliance: Gdnf^tm2Bbd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:33809
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Replacement of exon 2 with a neomycin cassette. (J:33809)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gdnf Mutation: 19 strains or lines available

References

• Original: J:33809 Sanchez MP, et al., Renal agenesis and the absence of enteric neurons in mice lacking GDNF. Nature. 1996 Jul 4;382(6586):70-3
• All: 9 reference(s)