Gdnf^tm1Lmgd
Targeted Allele Detail

Summary

• Symbol: Gdnf^tm1Lmgd
• Name: glial cell line derived neurotrophic factor; targeted mutation 1, Laboratory of Mammalian Genes and Development, Heiner Westphal
• MGI ID: MGI:2136846
• Synonyms: Gdnf-
• Gene: Gdnf Location: Chr15:7840327-7867056 bp, + strand Genetic Position: Chr15, 3.8 cM
• Alliance: Gdnf^tm1Lmgd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:33810
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Replacement of part of the third exon with a neomycin cassette. (J:33810)

Disease models

Expression

In Mice Carrying this Mutation:	14 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	20 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gdnf Mutation: 19 strains or lines available

Notes

ES cell line = J1 (129S4/SvJae) or R1 ((129X1/SvJ x 129S1/Sv)F1-Kitl⁺).

References

• Original: J:33810 Pichel JG, et al., Defects in enteric innervation and kidney development in mice lacking GDNF. Nature. 1996 Jul 4;382(6586):73-6
• All: 47 reference(s)