Ret^tm1Cos
Targeted Allele Detail

Summary

• Symbol: Ret^tm1Cos
• Name: ret proto-oncogene; targeted mutation 1, Frank Costantini
• MGI ID: MGI:2136894
• Synonyms: c-ret-, Ret-, ret-k-
• Gene: Ret Location: Chr6:118128706-118174679 bp, - strand Genetic Position: Chr6, 55.86 cM, cytoband E3-F1
• Alliance: Ret^tm1Cos page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:23852
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A neomycin resistance cassette replaced 0.8 kb of sequence, including the codon for an invariant lysine required for kinase activity. Northern blot analysis did not detect normal transcripts in brains of homozygous mice, but did detect several transcripts with sizes consistent with predicted products of the mutant allele. (J:23852)

Generation of the Ret^tm6.1Vpa and Ret^tm6.2Vpa alleles

Disease models

Expression

In Mice Carrying this Mutation:	49 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	15 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Ret Mutation: 54 strains or lines available

References

• Original: J:23852 Schuchardt A, et al., Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret [see comments]. Nature. 1994 Jan 27;367(6461):380-3
• All: 58 reference(s)