Il15^tm1Imx
Targeted Allele Detail

Summary

• Symbol: Il15^tm1Imx
• Name: interleukin 15; targeted mutation 1, Immunex Research and Development Corporation
• MGI ID: MGI:2136897
• Synonyms: Il15-, IL-15-
• Gene: Il15 Location: Chr8:83058261-83129851 bp, - strand Genetic Position: Chr8, 39.33 cM
• Alliance: Il15^tm1Imx page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:60915
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced 7.5kb of sequence containing exons 3-5, which encode amino acids 1-65. (J:60915)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 5 strains available Cell Lines: 0 lines available
• Carrying any Il15 Mutation: 44 strains or lines available

Notes

ES cell line was derived from C57BL/6; substrain not specified.

References

• Original: J:60915 Kennedy MK, et al., Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice [see comments]. J Exp Med. 2000 Mar 6;191(5):771-80
• All: 204 reference(s)