Bmp6^tm1Rob
Targeted Allele Detail

Summary

• Symbol: Bmp6^tm1Rob
• Name: bone morphogenetic protein 6; targeted mutation 1, Elizabeth J Robertson
• MGI ID: MGI:2136985
• Gene: Bmp6 Location: Chr13:38529098-38684283 bp, + strand Genetic Position: Chr13, 18.15 cM
• Alliance: Bmp6^tm1Rob page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:48561
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A ~1 kb genomic fragment containing 84 bp of exon 2 was replaced with a neomycin selection cassette. These sequences encode a portion of the pro-polypeptide region. RNAse protection assays on total RNA derived from kidney and brain of homozygous mice demonstrated that no detectable transcript was produced from this allele. (J:48561)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Bmp6 Mutation: 32 strains or lines available

References

• Original: J:48561 Solloway MJ, et al., Mice lacking Bmp6 function. Dev Genet. 1998;22(4):321-39
• All: 20 reference(s)