Bmp7^tm2Rob
Targeted Allele Detail

Summary

• Symbol: Bmp7^tm2Rob
• Name: bone morphogenetic protein 7; targeted mutation 2, Elizabeth J Robertson
• MGI ID: MGI:2136986
• Synonyms: BMP7/lacZ, BMP7^lacZ
• Gene: Bmp7 Location: Chr2:172709805-172782114 bp, - strand Genetic Position: Chr2, 95.54 cM
• Alliance: Bmp7^tm2Rob page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:50004
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A lacZ gene followed by a neomycin selection cassette replaced a 263 bp DNA fragment containing the endogenous translation start site. A beta-galactosidase protein is expressed from this allele under the control of the endogenous promoter, but the expression pattern does not faithfully reflect the expression pattern of the endogenous gene. (J:50004)

Expression

In Mice Carrying this Mutation:	258 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Bmp7 Mutation: 37 strains or lines available

References

• Original: J:50004 Godin RE, et al., Regulation of BMP7 expression during kidney development. Development. 1998 Sep;125(17):3473-82
• All: 31 reference(s)