Ntn1^{Gt(IRESBetageo)1Pgr}
Gene trapped Allele Detail

Summary

• Symbol: Ntn1^{Gt(IRESBetageo)1Pgr}
• Name: netrin 1; gene trap 1, Peter Gruss
• MGI ID: MGI:2137018
• Gene: Ntn1 Location: Chr11:68100190-68277652 bp, - strand Genetic Position: Chr11, 41.45 cM, cytoband B3
• Alliance: Ntn1^{Gt(IRESBetageo)1Pgr} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:57002
• Parent Cell Line: MPI-II (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: The gene trap integration event occurred in an intron of the netrin 1 gene. Integration of the vector resulted in the production of a transcript that included sequences from the 5' end of the gene fused to the vector sequences. Two translation products were produced from this allele: an N-terminal truncated form of the protein including the signal peptide and domains V1 and an IRES driving expression of beta-geo. (J:57002)

Expression

In Mice Carrying this Mutation:	79 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ntn1 Mutation: 107 strains or lines available

Notes

Homozygous mutant mice have commissural defects resembling those of mice homozygous for Dcc^tm1Wbg.

References

• Original: J:40076 Chowdhury K, et al., Evidence for the stochastic integration of gene trap vectors into the mouse germline. Nucleic Acids Res. 1997 Apr 15;25(8):1531-6
• All: 7 reference(s)