Nrp2^tm1Ddg
Targeted Allele Detail

Summary

• Symbol: Nrp2^tm1Ddg
• Name: neuropilin 2; targeted mutation 1, David D Ginty
• MGI ID: MGI:2137037
• Synonyms: Npn-2^-, nrp2^-
• Gene: Nrp2 Location: Chr1:62742476-62857851 bp, + strand Genetic Position: Chr1, 31.35 cM, cytoband C2
• Alliance: Nrp2^tm1Ddg page

Abnormal lymphatic development in Nrp2^tm1Ddg/Nrp2⁺ Flt4^tm1Ali/Flt4⁺ mice

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:60149
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 and 1.7 kb upstream of exon 1 were replaced with a neo-derived targeting vector by homologous recombination. Northern blot analysis of homozygous embryos demonstrated that no detectable transcript was expressed. Western blot on extracts derived from brain of homozygous animals did not detect any protein product. (J:60149)

Expression

In Mice Carrying this Mutation:

57 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nrp2 Mutation: 89 strains or lines available

References

• Original: J:60149 Giger RJ, et al., Neuropilin-2 is required in vivo for selective axon guidance responses to secreted semaphorins. Neuron. 2000 Jan;25(1):29-41
• All: 49 reference(s)