Dvl1^tm1Awb
Targeted Allele Detail

Summary

• Symbol: Dvl1^tm1Awb
• Name: dishevelled segment polarity protein 1; targeted mutation 1, Anthony Wynshaw-Boris
• MGI ID: MGI:2137230
• Synonyms: Dvl1-, Dvl1^del131-225
• Gene: Dvl1 Location: Chr4:155931859-155943760 bp, + strand Genetic Position: Chr4, 87.61 cM
• Alliance: Dvl1^tm1Awb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:42758
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced a genomic fragment containing part of exon 2 and exons 3 and 4, which encode amino acids 131-225. Western blot analysis on embryonic fibroblasts derived from homozygous mice confirmed that no detectable protein was produced from this allele. (J:42758)

Expression

In Mice Carrying this Mutation:

17 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Dvl1 Mutation: 35 strains or lines available

References

• Original: J:42758 Lijam N, et al., Social interaction and sensorimotor gating abnormalities in mice lacking Dvl1. Cell. 1997 Sep 5;90(5):895-905
• All: 21 reference(s)