Aplp2^tm1Dbo
Targeted Allele Detail

Summary

• Symbol: Aplp2^tm1Dbo
• Name: amyloid beta precursor-like protein 2; targeted mutation 1, David R Borchelt
• MGI ID: MGI:2137246
• Synonyms: APLP2^-
• Gene: Aplp2 Location: Chr9:31060853-31123111 bp, - strand Genetic Position: Chr9, 16.66 cM, cytoband A2-B
• Alliance: Aplp2^tm1Dbo page

Neuromuscular synapse defects in App^tm3.1Zhe/App^tm3.1Zhe Aplp2^tm1Dbo/Aplp2^tm1Dbo mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:45851
• Parent Cell Line: AB2.1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Replacement of the promoter region and first exon with a neomycin cassette. Western blot analysis on samples derived from nervous tissue and other peripheral tissues of homozygous mutant mice failed to detect any protein. (J:45851)

Expression

In Mice Carrying this Mutation:

26 assay results 3 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Aplp2 Mutation: 32 strains or lines available

References

• Original: J:45851 von Koch CS, et al., Generation of APLP2 KO mice and early postnatal lethality in APLP2/APP double KO mice. Neurobiol Aging. 1997 Nov-Dec;18(6):661-9
• All: 48 reference(s)