Sox1^tm1Vep
Targeted Allele Detail

Summary

• Symbol: Sox1^tm1Vep
• Name: SRY (sex determining region Y)-box 1; targeted mutation 1, Vasso Episkopou
• MGI ID: MGI:2137412
• Synonyms: SOX1^beta-geo, Sox1^lacZ, Sox1^M1, Sox1^MI
• Gene: Sox1 Location: Chr8:12445519-12449555 bp, + strand Genetic Position: Chr8, 5.73 cM, cytoband A1-A2
• Alliance: Sox1^tm1Vep page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:46636
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Most of the coding region was replaced with an in-frame beta-geo expression gene. (J:46636)

Expression

In Mice Carrying this Mutation:	9 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sox1 Mutation: 13 strains or lines available

References

• Original: J:46636 Nishiguchi S, et al., Sox1 directly regulates the gamma-crystallin genes and is essential for lens development in mice. Genes Dev. 1998 Mar 15;12(6):776-81
• All: 9 reference(s)