Gabra1^tm1.1Geh
Targeted Allele Detail

Summary

• Symbol: Gabra1^tm1.1Geh
• Name: gamma-aminobutyric acid type A receptor subunit alpha 1; targeted mutation 1.1, Gregg E Homanics
• MGI ID: MGI:2137421
• Synonyms: alpha1^-, alpha1⁰
• Gene: Gabra1 Location: Chr11:42021766-42073757 bp, - strand Genetic Position: Chr11, 24.97 cM
• Alliance: Gabra1^tm1.1Geh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:70505
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele is a derivative of Gabra1^tm1Geh in which the loxP flanked sequences were deleted in the germline by crossing mice carrying this allele to mice carrying a ubiquitously expressed Cre recombinase. (J:70505)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gabra1 Mutation: 48 strains or lines available

References

• Original: J:70505 Vicini S, et al., GABA(A) receptor alpha1 subunit deletion prevents developmental changes of inhibitory synaptic currents in cerebellar neurons. J Neurosci. 2001 May 1;21(9):3009-16
• All: 24 reference(s)