Hectd1^opm
Chemically induced Allele Detail

Summary

• Symbol: Hectd1^opm
• Name: HECT domain E3 ubiquitin protein ligase 1; open mind
• MGI ID: MGI:2137552
• Synonyms: opm
• Gene: Hectd1 Location: Chr12:51790505-51876319 bp, - strand Genetic Position: Chr12, 22.11 cM
• Alliance: Hectd1^opm page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU) (Null/knockout)
• Mutation: Single point mutation
• Mutation details: An ENU-induced T-to-A mutation changes leucine codon 144 to a premature stop codon (total peptide length is 2611 amino acids). The resulting truncated protein, which is probably not expressed, lacks an ankyrin repeat, a mib domain and a terminal HECT domain. (J:122594)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	30 assay results
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hectd1 Mutation: 142 strains or lines available

References

• Original: J:48268 Kasarskis A, et al., A phenotype-based screen for embryonic lethal mutations in the mouse. Proc Natl Acad Sci U S A. 1998 Jun 23;95(13):7485-90
• All: 8 reference(s)