Thrb^tm1.1Syc
Targeted Allele Detail

Summary

• Symbol: Thrb^tm1.1Syc
• Name: thyroid hormone receptor beta; targeted mutation 1.1, Sheue-yann Cheng
• MGI ID: MGI:2137592
• Synonyms: TRbeta PV, TRbeta^PV, TRbetaPV
• Gene: Thrb Location: Chr14:4431611-4809435 bp, - strand Genetic Position: Chr14, 7.08 cM, cytoband A3
• Alliance: Thrb^tm1.1Syc page

Histology of thyroid glands of wild-type, Thrb^tm1.1Syc/Thrb⁺ and Thrb^tm1.1Syc/Thrb^tm1.1Syc mice.

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:65885
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: Mice homozygous for the Thrb^tm1Syc allele were mated to EIIa-Cre transgenic mice to generate mice that carry a germline deletion of the neomycin resistance gene. RT-PCR studies of liver and brown adipocytes from mice homozygous for the final allele indicate that the mutant allele is expressed at the RNA level in expected T3 target tissues. Northern analyses of liver, heart, and brain indicate that levels of transcription of both the mutated and wild-type alleles were not significantly different in heterozygous and homozygous mutant mice, and wild-type mice. (J:65885)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	17 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Thrb^tm1.1Syc

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Thrb Mutation: 41 strains or lines available

References

• Original: J:65885 Kaneshige M, et al., Mice with a targeted mutation in the thyroid hormone beta receptor gene exhibit impaired growth and resistance to thyroid hormone. Proc Natl Acad Sci U S A. 2000 Nov 21;97(24):13209-14
• All: 61 reference(s)