Mme^tm1Cge
Targeted Allele Detail

Summary

• Symbol: Mme^tm1Cge
• Name: membrane metallo endopeptidase; targeted mutation 1, Craig Gerard
• MGI ID: MGI:2137696
• Synonyms: NEP-
• Gene: Mme Location: Chr3:63202632-63291134 bp, + strand Genetic Position: Chr3, 29.97 cM
• Alliance: Mme^tm1Cge page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:70516
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neomycin resistance cassette replaced 0.6kb of sequence containing exon 13 and part of intron 13. Northern blot analysis using a cDNA probe for the active site region, exons 14 - 20, did not detect message in renal tissue from homozygous mutant pups. (J:70516)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mme Mutation: 61 strains or lines available

References

• Original: J:70516 Lu B, et al., Neutral endopeptidase modulation of septic shock. J Exp Med. 1995 Jun 1;181(6):2271-5
• All: 33 reference(s)