Hadha^tm1Jib
Targeted Allele Detail

Summary

• Symbol: Hadha^tm1Jib
• Name: hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha; targeted mutation 1, Jamal A Ibdah
• MGI ID: MGI:2137697
• Synonyms: Mtpa-
• Gene: Hadha Location: Chr5:30324421-30359978 bp, - strand Genetic Position: Chr5, 15.95 cM
• Alliance: Hadha^tm1Jib page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:69846
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced 1.6kb of sequence containing exon 1, flanking 5' sequences, and part of intron 1. Northern blot analysis of total RNA did not detect mRNA in liver and heart of homozygous mutant newborn pups. Western blot analysis did not detect protein in extracts of liver and heart tissue of homozygous mutant newborn pups. (J:69846)

Expression

In Mice Carrying this Mutation:	12 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hadha Mutation: 33 strains or lines available

References

• Original: J:69846 Ibdah JA, et al., Lack of mitochondrial trifunctional protein in mice causes neonatal hypoglycemia and sudden death. J Clin Invest. 2001 Jun;107(11):1403-9
• All: 5 reference(s)