Ptger1^tm1Sna
Targeted Allele Detail

Summary

• Symbol: Ptger1^tm1Sna
• Name: prostaglandin E receptor 1 (subtype EP1); targeted mutation 1, Shuh Narumiya
• MGI ID: MGI:2137762
• Synonyms: EP1-, Ptger1-
• Gene: Ptger1 Location: Chr8:84393307-84399382 bp, + strand Genetic Position: Chr8, 40.22 cM
• Alliance: Ptger1^tm1Sna page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:70534
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Insertion of a neomycin resistance cassette into the FspI site of exon 2, located immediately before the sequence encoding the first transmembrane domain. Northern blots of renal tissue did not detect Ptger1 transcript in homozygous mutant mice. (J:70534)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Ptger1^tm1Sna

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ptger1 Mutation: 22 strains or lines available

References

• Original: J:70534 Ushikubi F, et al., Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3. Nature. 1998 Sep 17;395(6699):281-4
• All: 46 reference(s)