Mapt^tm1Noh
Targeted Allele Detail

Summary

• Symbol: Mapt^tm1Noh
• Name: microtubule-associated protein tau; targeted mutation 1, Nobutaka Hirokawa
• MGI ID: MGI:2138030
• Synonyms: tau-
• Gene: Mapt Location: Chr11:104122216-104222916 bp, + strand Genetic Position: Chr11, 67.79 cM, cytoband E1
• Alliance: Mapt^tm1Noh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:19030
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A PGK-neomycin cassette was inserted into exon 1 of the gene. Mapt protein was not detected by Western blot using anti-Mapt antibodies in crude extracts from cerebrum and cerebellum or the dorsal root ganglia of homozygous mutant mice. (J:19030)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mapt Mutation: 430 strains or lines available

References

• Original: J:19030 Harada A, et al., Altered microtubule organization in small-calibre axons of mice lacking tau protein. Nature. 1994 Jun 9;369(6480):488-91
• All: 6 reference(s)