Aplp2^tm1Min
Targeted Allele Detail

Summary

• Symbol: Aplp2^tm1Min
• Name: amyloid beta precursor-like protein 2; targeted mutation 1, Minoo Rassoulzadegan
• MGI ID: MGI:2138038
• Gene: Aplp2 Location: Chr9:31060853-31123111 bp, - strand Genetic Position: Chr9, 16.66 cM, cytoband A2-B
• Alliance: Aplp2^tm1Min page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:49466
• Parent Cell Line: WW6 (ES Cell)
• Strain of Origin: STOCK 129/Sv and C57BL/6J and SJL

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced sequences between exon 4 and exon 15, deleting 11.35 kb of the gene. (J:49466)

Expression

In Mice Carrying this Mutation:

2 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aplp2 Mutation: 32 strains or lines available

References

• Original: J:49466 Rassoulzadegan M, et al., APLP2, a member of the Alzheimer precursor protein family, is required for correct genomic segregation in dividing mouse cells. EMBO J. 1998 Aug 17;17(16):4647-56
• All: 2 reference(s)