Lamb2^tm1Jrs
Targeted Allele Detail

Summary

• Symbol: Lamb2^tm1Jrs
• Name: laminin, beta 2; targeted mutation 1, Joshua R Sanes
• MGI ID: MGI:2138070
• Synonyms: beta2, Lamb2-
• Gene: Lamb2 Location: Chr9:108357080-108367729 bp, + strand Genetic Position: Chr9, 59.4 cM, cytoband F1
• Alliance: Lamb2^tm1Jrs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:23783
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Insertion of a neomycin cassette into the second exon of the gene. (J:23783)

Disease models

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lamb2 Mutation: 76 strains or lines available

Notes

Phenotypic Similarity to Human Syndrome: human congenital or idiopathic nephritic syndromes such as minimal change nephrotic syndrome (MCNS) and glomerulonephrosis (J:27732).

References

• Original: J:23783 Noakes PG, et al., Aberrant differentiation of neuromuscular junctions in mice lacking s-laminin/laminin beta 2. Nature. 1995 Mar 16;374(6519):258-62
• All: 30 reference(s)