Rapsn^tm1Jrs
Targeted Allele Detail

Summary

• Symbol: Rapsn^tm1Jrs
• Name: receptor-associated protein of the synapse; targeted mutation 1, Joshua R Sanes
• MGI ID: MGI:2148091
• Gene: Rapsn Location: Chr2:90865965-90876074 bp, + strand Genetic Position: Chr2, 50.44 cM
• Alliance: Rapsn^tm1Jrs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:28777
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced approximately 1kb of genomic sequence including part of exon 3 and intron 3. Western blot analysis did not detect the protein in muscle of homozygous mutant mice. (J:28777)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rapsn Mutation: 31 strains or lines available

References

• Original: J:28777 Gautam M, et al., Failure of postsynaptic specialization to develop at neuromuscular junctions of rapsyn-deficient mice [see comments]. Nature. 1995 Sep 21;377(6546):232-6
• All: 13 reference(s)