Mstn^tm1Sjl
Targeted Allele Detail

Summary

• Symbol: Mstn^tm1Sjl
• Name: myostatin; targeted mutation 1, Se-Jin Lee
• MGI ID: MGI:2148177
• Synonyms: mstn^-, MSTN-KO
• Gene: Mstn Location: Chr1:53100799-53107238 bp, + strand Genetic Position: Chr1, 26.99 cM
• Alliance: Mstn^tm1Sjl page

Skeletal defects in Gdf11^tm1Sjl/Gdf11^tm1Sjl and Mstn^tm1Sjl/Mstn^tm1Sjl Gdf11^tm1Sjl/Gdf11^tm1Sjl newborn mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:40054
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Replacement of the sequences encoding the entire C-terminal region of the protein with a neomycin cassette. (J:40054)

Disease models

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Mstn Mutation: 34 strains or lines available

References

• Original: J:40054 McPherron AC, et al., Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member. Nature. 1997 May 1;387(6628):83-90
• All: 89 reference(s)