Tcf21^tm2Eno
Targeted Allele Detail

Summary

• Symbol: Tcf21^tm2Eno
• Name: transcription factor 21; targeted mutation 2, Eric N Olson
• MGI ID: MGI:2148205
• Synonyms: cap^lacZ, capsulin^LacZ, Tcf21^lacZ
• Gene: Tcf21 Location: Chr10:22693162-22696042 bp, - strand Genetic Position: Chr10, 10.33 cM
• Alliance: Tcf21^tm2Eno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:64068
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: Insertion of an in-frame lacZ gene into the first exon after the initiation codon. A neomycin resistance cassette was also inserted following the lacZ gene. (J:64068)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	28 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tcf21 Mutation: 16 strains or lines available

References

• Original: J:64068 Lu J, et al., The basic helix-loop-helix transcription factor capsulin controls spleen organogenesis. Proc Natl Acad Sci U S A. 2000 Aug 15;97(17):9525-30
• All: 7 reference(s)