Tcf21^tm1Jrt
Targeted Allele Detail

Summary

• Symbol: Tcf21^tm1Jrt
• Name: transcription factor 21; targeted mutation 1, Janet Rossant
• MGI ID: MGI:2148207
• Synonyms: pod1^-, pod1/lacZ, Tcf21^LacZ
• Gene: Tcf21 Location: Chr10:22693162-22696042 bp, - strand Genetic Position: Chr10, 10.33 cM
• Alliance: Tcf21^tm1Jrt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:55785
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Replacement of the initiation codon and sequences encoding the bHLH domain with an in-frame lacZ gene and neomycin resistance cassette. (J:55785)

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	23 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tcf21 Mutation: 16 strains or lines available

References

• Original: J:55785 Quaggin SE, et al., The basic-helix-loop-helix protein pod1 is critically important for kidney and lung organogenesis. Development. 1999 Dec;126(24):5771-83
• All: 12 reference(s)