Neurod1^tm1Mjts
Targeted Allele Detail

Summary

• Symbol: Neurod1^tm1Mjts
• Name: neurogenic differentiation 1; targeted mutation 1, Ming-Jer Tsai
• MGI ID: MGI:2148229
• Synonyms: BETA2-
• Gene: Neurod1 Location: Chr2:79282981-79286980 bp, - strand Genetic Position: Chr2, 47.58 cM
• Alliance: Neurod1^tm1Mjts page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:43010
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neomycin cassette replaced all but the first 66 amino acids of the gene, deleting sequences encoding the basic helix-loop-helix (bHLH) and transactivation domains. (J:43010)

Disease models

Expression

In Mice Carrying this Mutation:	102 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	14 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Neurod1 Mutation: 29 strains or lines available

References

• Original: J:43010 Naya FJ, et al., Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice. Genes Dev. 1997 Sep 15;11(18):2323-34
• All: 22 reference(s)