Dmd^{Gt(ROSABetageo)1Mpd}
Gene trapped Allele Detail

Summary

• Symbol: Dmd^{Gt(ROSABetageo)1Mpd}
• Name: dystrophin, muscular dystrophy; gene trap 1, Karin Wertz
• MGI ID: MGI:2148259
• Synonyms: Dmd^mdx-betageo, mdx-betageo
• Gene: Dmd Location: ChrX:81992476-84249747 bp, + strand Genetic Position: ChrX, 38.38 cM, cytoband C
• Alliance: Dmd^{Gt(ROSABetageo)1Mpd} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:47968
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: Insertion of a gene trap vector resulted in aberrant splicing from exon 63 to the inserted Beta-geo gene. RT-PCR analysis demonstrated that the mRNA was mutated in this allele, although a very low level of wild-type transcript was detected in brain. Full length wild-type protein could not be detected by Western blotting in tissue extracts derived from hemizygous males. (J:47968)

Disease models

Expression

In Mice Carrying this Mutation:	57 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dmd Mutation: 154 strains or lines available

References

• Original: J:47968 Wertz K, et al., Dmd(mdx-beta geo): a new allele for the mouse dystrophin gene. Dev Dyn. 1998 Jun;212(2):229-41
• All: 13 reference(s)