Cdh5^tm2Pec
Targeted Allele Detail

Summary

• Symbol: Cdh5^tm2Pec
• Name: cadherin 5; targeted mutation 2, Peter Carmeliet
• MGI ID: MGI:2148549
• Synonyms: VE-cadherin^-, VEC^null
• Gene: Cdh5 Location: Chr8:104828257-104871143 bp, + strand Genetic Position: Chr8, 53.04 cM
• Alliance: Cdh5^tm2Pec page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:56509
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced a genomic fragment containing exons 3-7. Western blot analysis on endothelial cells derived from homozygous mice confirmed that no detectable protein was made. (J:56509)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdh5 Mutation: 59 strains or lines available

References

• Original: J:56509 Carmeliet P, et al., Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis. Cell. 1999 Jul 23;98(2):147-57
• All: 6 reference(s)