Ctnnb1^tm2.1Kem
Targeted Allele Detail

Summary

• Symbol: Ctnnb1^tm2.1Kem
• Name: catenin beta 1; targeted mutation 2.1 Rolf Kemler
• MGI ID: MGI:2148569
• Synonyms: beta-catenin^del, Ctnnb1^Del, floxdel
• Gene: Ctnnb1 Location: Chr9:120762466-120789573 bp, + strand Genetic Position: Chr9, 72.19 cM
• Alliance: Ctnnb1^tm2.1Kem page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:67966
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele is a derivative of Catnb^tm2Kem in which Cre mediated recombination removed exons 2 through 6. (J:67966)

Expression

In Mice Carrying this Mutation:	182 assay results 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	34 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ctnnb1 Mutation: 49 strains or lines available

References

• Original: J:67966 Brault V, et al., Inactivation of the beta-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development. Development. 2001 Apr;128(8):1253-64
• All: 54 reference(s)