Utrn^tm1Ked
Targeted Allele Detail

Summary

• Symbol: Utrn^tm1Ked
• Name: utrophin; targeted mutation 1, Kay E Davies
• MGI ID: MGI:2148589
• Synonyms: Utr^-
• Gene: Utrn Location: Chr10:12257932-12745109 bp, - strand Genetic Position: Chr10, 3.77 cM
• Alliance: Utrn^tm1Ked page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:70949
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Insertion of a neomycin cassette into exon 7. No protein was detected in extracts derived from kidney, lung or brain of homozygous mice as assayed by Western blot analysis. (J:70949)

Disease models

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 7 strains available Cell Lines: 0 lines available
• Carrying any Utrn Mutation: 304 strains or lines available

References

• Original: J:70949 Deconinck AE, et al., Postsynaptic abnormalities at the neuromuscular junctions of utrophin-deficient mice. J Cell Biol. 1997 Feb 24;136(4):883-94
• All: 72 reference(s)