Krt14^{tm1.1(cre)Wbm}
Targeted Allele Detail

Summary

• Symbol: Krt14^{tm1.1(cre)Wbm}
• Name: keratin 14; targeted mutation 1.1, Walter Birchmeier
• MGI ID: MGI:2148597
• Synonyms: K14-cre(deltaneo)
• Gene: Krt14 Location: Chr11:100093988-100098336 bp, - strand Genetic Position: Chr11, 63.43 cM, cytoband D
• Alliance: Krt14^{tm1.1(cre)Wbm} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:69463
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Krt14^{tm1.1(cre)Wbm} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Krt14 (MGI:96688)

• Mutation details: A cre gene was inserted in frame into the gene immediately following the endogenous start codon. An frt-flanked neomycin selection cassette that was inserted following the cre gene was removed by Flp-mediated recombination in ES cells prior to production of chimeric mice. This promoter is active after birth in the epidermis and hair follicles as well as the eye, tongue, and esophagus. (J:69463)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Krt14 (mouse) Summary of all recombinase alleles driven by Krt14. Comparative matrix view of recombinase activities Alliance mouse Krt14 gene page

Disease models

Expression

In Mice Carrying this Mutation:

2 assay results 1 RNA-Seq or microarray experiment(s)

Tumor Data

List all tumor models in MMHCdb carrying Krt14^{tm1.1(cre)Wbm}

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Krt14 Mutation: 38 strains or lines available

References

• Original: J:69463 Huelsken J, et al., beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin. Cell. 2001 May 18;105(4):533-45
• All: 18 reference(s)