Maf^tm1Glm
Targeted Allele Detail

Summary

• Symbol: Maf^tm1Glm
• Name: MAF bZIP transcription factor; targeted mutation 1, Laurie H Glimcher
• MGI ID: MGI:2148636
• Synonyms: c-maf-, Maf-
• Gene: Maf Location: Chr8:116429992-116433633 bp, - strand Genetic Position: Chr8, 62.61 cM
• Alliance: Maf^tm1Glm page

Histological analysis of the lens from Maf^tm1Glm/Maf⁺ and Maf^tm1Glm/Maf^tm1Glm mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:54079
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Insertion of a neomycin cassette into the codon corresponding to amino acid 170 of the encoded protein. No protein was detected in kidney extracts derived from homozygous mice. (J:54079)

Expression

In Mice Carrying this Mutation:	24 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Maf Mutation: 27 strains or lines available

References

• Original: J:54079 Kim JI, et al., Requirement for the c-Maf transcription factor in crystallin gene regulation and lens development. Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3781-5
• All: 13 reference(s)