Adra1b^tm1Cta
Targeted Allele Detail

Summary

• Symbol: Adra1b^tm1Cta
• Name: adrenergic receptor, alpha 1b; targeted mutation 1, Susanna Cotecchia
• MGI ID: MGI:2148638
• Synonyms: alpha1b-, alpha1b-AR-
• Gene: Adra1b Location: Chr11:43665433-43792037 bp, - strand Genetic Position: Chr11, 25.81 cM
• Alliance: Adra1b^tm1Cta page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:43591
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment containing exon 1 was deleted and replaced with a neomycin selection cassette. RT-PCR analysis confirmed that no transcript is produced from this allele. (J:43591)

Expression

In Structures Affected by this Mutation:

15 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Adra1b Mutation: 19 strains or lines available

References

• Original: J:43591 Cavalli A, et al., Decreased blood pressure response in mice deficient of the alpha1b-adrenergic receptor. Proc Natl Acad Sci U S A. 1997 Oct 14;94(21):11589-94
• All: 29 reference(s)