Six5^tm1Rdd
Targeted Allele Detail

Summary

• Symbol: Six5^tm1Rdd
• Name: sine oculis-related homeobox 5; targeted mutation 1, Sita Reddy
• MGI ID: MGI:2148689
• Gene: Six5 Location: Chr7:18828519-18832474 bp, + strand Genetic Position: Chr7, 9.46 cM
• Alliance: Six5^tm1Rdd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:61881
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Replacement of the entire coding region of the gene, including 398 bp upstream of the start codon and 180 bp downstream of the termination codon, with a neomycin cassette. (J:61881)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Six5 Mutation: 23 strains or lines available

References

• Original: J:61881 Sarkar PS, et al., Heterozygous loss of Six5 in mice is sufficient to cause ocular cataracts. Nat Genet. 2000 May;25(1):110-4
• All: 5 reference(s)