Six5^tm1Tap
Targeted Allele Detail

Summary

• Symbol: Six5^tm1Tap
• Name: sine oculis-related homeobox 5; targeted mutation 1, Steven J Tapscott
• MGI ID: MGI:2148692
• Gene: Six5 Location: Chr7:18828519-18832474 bp, + strand Genetic Position: Chr7, 9.46 cM
• Alliance: Six5^tm1Tap page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:61882
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Replacement of much of the first exon with an in-frame lacZ gene. A loxP flanked neomycin resistance cassette inserted 3' to the lacZ gene was removed via Cre-mediated recombination in ES cells prior to the production of chimeric mice. Beta-galactosidase is expressed from this allele under the control of the endogenous promoter elements. (J:61882)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Six5 Mutation: 23 strains or lines available

References

• Original: J:61882 Klesert TR, et al., Mice deficient in Six5 develop cataracts: implications for myotonic dystrophy. Nat Genet. 2000 May;25(1):105-9
• All: 6 reference(s)