Pon1^tm1Lus
Targeted Allele Detail

Summary

• Symbol: Pon1^tm1Lus
• Name: paraoxonase 1; targeted mutation 1, Aldons J Lusis
• MGI ID: MGI:2148702
• Synonyms: PON1⁰
• Gene: Pon1 Location: Chr6:5168101-5193824 bp, - strand Genetic Position: Chr6, 1.99 cM, cytoband A2
• Alliance: Pon1^tm1Lus page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:63392
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Exon 1 is disrupted with a neomycin resistance gene via homlogous recombination. Plasma from homozygous mutant animals did not demonstrate paraoxonase activity and did not contain protein product as assayed by Western blot. (J:63392)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pon1 Mutation: 25 strains or lines available

References

• Original: J:63392 Shih DM, et al., Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and atherosclerosis. Nature. 1998 Jul 16;394(6690):284-7
• All: 18 reference(s)