Scap^tm1Mbjg
Targeted Allele Detail

Summary

• Symbol: Scap^tm1Mbjg
• Name: SREBF chaperone; targeted mutation 1, Joseph L Goldstein
• MGI ID: MGI:2148743
• Synonyms: Scap-, SCAP^flox, Scap^tm1Gsn
• Gene: Scap Location: Chr9:110162356-110214017 bp, + strand Genetic Position: Chr9, 59.91 cM
• Alliance: Scap^tm1Mbjg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:69592
• Parent Cell Line: SM1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A a loxP-flanked neomycin resistance cassette located 3 kb upstream of exon 1. An additional loxP site was inserted in intron 1. (J:69592)

Expression

In Mice Carrying this Mutation:	12 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Scap Mutation: 62 strains or lines available

References

• Original: J:69592 Matsuda M, et al., SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation. Genes Dev. 2001 May 15;15(10):1206-16
• All: 38 reference(s)