Emx2^tm1Pgr
Targeted Allele Detail

Summary

• Symbol: Emx2^tm1Pgr
• Name: empty spiracles homeobox 2; targeted mutation 1, Peter Gruss
• MGI ID: MGI:2148858
• Synonyms: Emx-, Emx2-, Emx2^KO
• Gene: Emx2 Location: Chr19:59447122-59453789 bp, + strand Genetic Position: Chr19, 56.28 cM
• Alliance: Emx2^tm1Pgr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:37631
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 250 bp PvuII-PvuII fragment in the sequences encoding the 5' part of the homeobox was replaced with a neomycin cassette. (J:37631)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	214 assay results
In Structures Affected by this Mutation:	13 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Emx2 Mutation: 24 strains or lines available

References

• Original: J:37631 Pellegrini M, et al., Dentate gyrus formation requires Emx2. Development. 1996 Dec;122(12):3893-8
• All: 41 reference(s)