Insl3^tm1Par
Targeted Allele Detail

Summary

• Symbol: Insl3^tm1Par
• Name: insulin-like 3; targeted mutation 1, Luis F Parada
• MGI ID: MGI:2148889
• Synonyms: Insl3-
• Gene: Insl3 Location: Chr8:72141896-72143221 bp, + strand Genetic Position: Chr8, 34.43 cM
• Alliance: Insl3^tm1Par page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:55881
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An IRES-lacZ-PGK-neomycin resistance cassette replaced a 1190 bp region containing the complete coding sequence for the gene. In situ studies of testis did not detect Insl3 expression in Leydig cells from homozygous mutant mice. Expression of the inserted lacZ gene was not reported. (J:55881)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Insl3 Mutation: 7 strains or lines available

References

• Original: J:55881 Nef S, et al., Cryptorchidism in mice mutant for Insl3. Nat Genet. 1999 Jul;22(3):295-9
• All: 3 reference(s)