Hoxc8^tm1Phb
Targeted Allele Detail

Summary

• Symbol: Hoxc8^tm1Phb
• Name: homeobox C8; targeted mutation 1, Philippe Brulet
• MGI ID: MGI:2149030
• Synonyms: Hox-3.1^-, Hoxc-8^-, Hoxc-8^lacZ
• Gene: Hoxc8 Location: Chr15:102899039-102902543 bp, + strand Genetic Position: Chr15, 58.05 cM
• Alliance: Hoxc8^tm1Phb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:590
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Insertion of a lacZ gene and deletion of codons 2-42 in the coding region. A HOXC8-beta galactosidase fusion protein is expressed from this allele. (J:590)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	107 assay results
In Structures Affected by this Mutation:	11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hoxc8 Mutation: 8 strains or lines available

References

• Original: J:590 Le Mouellic H, et al., Homeosis in the mouse induced by a null mutation in the Hox-3.1 gene. Cell. 1992 Apr 17;69(2):251-64
• All: 8 reference(s)