Pik3r1^tm1Tka
Targeted Allele Detail

Summary

• Symbol: Pik3r1^tm1Tka
• Name: phosphoinositide-3-kinase regulatory subunit 1; targeted mutation 1, Takashi Kadowaki
• MGI ID: MGI:2149414
• Synonyms: p85alpha-, PI3K p85alpha^-, Pi3kr1-
• Gene: Pik3r1 Location: Chr13:101817269-101904725 bp, - strand Genetic Position: Chr13, 53.92 cM
• Alliance: Pik3r1^tm1Tka page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:52576
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin cassette replaced the first exon, exon 1A, of the gene. Functional analysis showed that deletion of this exon, which contains the initiation codon, abolished expression of the p85a variant, while not disrupting expression of the p50a or p55a splicing variants. (J:52576)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Pik3r1 Mutation: 56 strains or lines available

References

• Original: J:52576 Terauchi Y, et al., Increased insulin sensitivity and hypoglycaemia in mice lacking the P85 alpha subunit of phosphoinositide 3- kinase. Nat Genet. 1999 FEB;21(2):230-235
• All: 49 reference(s)