Pik3r1^tm1Dfr
Targeted Allele Detail

Summary

• Symbol: Pik3r1^tm1Dfr
• Name: phosphoinositide-3-kinase regulatory subunit 1; targeted mutation 1, David A Fruman
• MGI ID: MGI:2149438
• Synonyms: p85alpha-, p85a-p55a-p50a-
• Gene: Pik3r1 Location: Chr13:101817269-101904725 bp, - strand Genetic Position: Chr13, 53.92 cM
• Alliance: Pik3r1^tm1Dfr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:52229
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin cassette replaced the last five exons (11 - 15) of the gene, which are common to all known splice variants. (J:52229)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pik3r1 Mutation: 56 strains or lines available

References

• Original: J:52229 Fruman DA, et al., Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha. Science. 1999 Jan 15;283(5400):393-7
• All: 18 reference(s)